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& Turkheimer, F

Consequently, gas exchange is obstructed, and edema develops, causing diffuse alveolar damage (DAD) and the formation of a hyaline membrane along the alveolar walls, which is visible radiologically as patchy ground-glass patterns [6]

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The continuous ECM deposition in the lung interstitium between alveoli and capillaries leads to irreversible structural changes and lung damage ( Alveolar epithelial wound repair is a complex, coordinated process